120786-18-7
- Product Name：Huperzine A
- Molecular Formula：C15H18N2O
- Purity：99%
- Molecular Weight：242.321
Reputable factory supply Huperzine A 120786-18-7 in bulk at low price
- Molecular Formula:C15H18N2O
- Molecular Weight:242.321
- Appearance/Colour:Brown to White Powder
- Refractive Index:1.626
- Boiling Point:505 °C at 760 mmHg
- PKA:12.25±0.60(Predicted)
- Flash Point:259.2 °C
- PSA：58.88000
- Density:1.2 g/cm3
- LogP:2.69780
Huperzine A(Cas 120786-18-7) Usage
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benefits |
Huperzine A can help support learning and memory by protecting acetylcholine, a neurotransmitter that acts as a messenger molecule in the brain. Huperzine A may be used for both short-term "brain boost" needs, such as preparing for a test, as well as more long-term needs, such as reducing the mild memory loss associated with normal aging.ACETYLCHOLINESTERASE INHIBITOR - Huperzine A acts as a reversible Acetylcholinesterase inhibitor meaning it supports levels of the neurotransmitter acetylcholine which plays a key role in cognitive function.SUPPORTS COGNITIVE FUNCTION - Supports working memory, motivation, and problem solving ability.SUPPORTS ENERGY AND STAMINA - Huperzine A supports mental energy, stamina, and sustained focus. |
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Biological Activity |
Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning. |
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Side effects |
When taken at recommended doses Huperzine A is well tolerated and presents few side effects. Rarely, side effects including nausea, diarrhea, and loss of appetite may occur. Adverse side effects are more likely when exceeding the recommended dosage.Huperzine A is not recommended for people suffering from heart conditions, consult your physician before taking this product. |
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Dosage forms |
Huperzine A supplementation tends to be in the range of 50 - 200 mcg daily. Our tablets are 200 mcg each, but can be easily broken into halves or quarters for those wishing to take smaller doses.Huperzine A has a long half-life (10-14 hours), so cycling this product is often recommended. We recommend taking it no more than 2-3 times per week, or if using it daily we recommend taking a 1 week break for every 2 weeks of use. |
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Application |
(±)-Huperzine A has been used in anti-acetylcholinesterase bioautographic assay. |
InChI:InChI=1/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
120786-18-7 Relevant articles
Synthetic method of huperzine A
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Paragraph 0075; 0077; 0118-0121, (2019/05/15)
The invention belongs to the technical f...
METHODS OF RESOLVING RACEMIC MIXTURE TO OBTAIN (-)-HUPERZINE A
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Page/Page column 10, (2016/04/26)
A method of resolving a racemic mixture ...
PREPARATION OF (-)-HUPERZINE A
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Paragraph 0128; 0129, (2016/06/28)
The present invention relates to a metho...
Cyclobutane Synthesis and Fragmentation. A Cascade Route to the Lycopodium Alkaloid (-)-Huperzine A
White, James D.,Li, Yang,Kim, Jungchul,Terinek, Miroslav
, p. 11806 - 11817 (2015/12/11)
An asymmetric total synthesis of the noo...
120786-18-7 Process route
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![methyl ((5S,E)-11-ethylidene-2-methoxy-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-5-yl)carbamate](/upload/2024/8/e92b1a26-cf0e-41ef-9500-602381c426d0.png)
- 185741-46-2
methyl ((5S,E)-11-ethylidene-2-methoxy-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-5-yl)carbamate
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- 92138-20-0,102518-79-6,103735-86-0,120786-18-7,130791-77-4,132435-40-6,116-28-9
natural Huperzine A
| Conditions | Yield |
|---|---|
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methyl ((5S,E)-11-ethylidene-2-methoxy-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-5-yl)carbamate; With trimethylsilyl iodide; In chloroform; for 6h; Reflux; Inert atmosphere;
With methanol; In chloroform; for 3h; Reflux; Inert atmosphere;
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80% |
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With trimethylsilyl iodide; In chloroform; for 6h; Reflux; Inert atmosphere;
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80% |
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methyl ((5S,E)-11-ethylidene-2-methoxy-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-5-yl)carbamate; With sodium iodide; In acetonitrile; at 20 ℃; for 0.166667h;
With chloro-trimethyl-silane; In acetonitrile; at 20 ℃; Reflux;
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46% |
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With methanol; trimethylsilyl iodide; Yield given. Multistep reaction; 1.) reflux, 12 h, 2.) reflux, 12 h.;
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C16H16N2O2
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- 92138-20-0,102518-79-6,103735-86-0,120786-18-7,130791-77-4,132435-40-6,116-28-9
natural Huperzine A
| Conditions | Yield |
|---|---|
|
With sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 36h;
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60% |
120786-18-7 Upstream products
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120686-05-7
(E)-(+/-)-(11-ethylidene-9,10-dihydro-2-methoxy-7-methyl-5,9-methanocyclooctapyridin-5(6H)-yl)carbamic acid methyl ester
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151619-29-3
[13-Eth-(E)-ylidene-5-methoxy-11-methylene-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-1-yl]-carbamic acid methyl ester
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134287-15-3
(E)-11-ethylidene-5,6,9,10-tetrahydro-5-(methoxycarbonylamino)-7-methyl-5,9-methano-1H-cycloocta[b]pyridin-2-one
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151619-37-3
13-Eth-(E)-ylidene-5-methoxy-11-methylene-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-1-carboxylic acid
120786-18-7 Downstream products
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92138-20-0
natural Huperzine A
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955117-18-7
(5R,9R,11E)-5-(3-phenylprop-2-en-1-ylideneamino)-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
